Publications based on pilot HaBio data

Ricardo de Matos Simoes, Sabine Dalleau, Kate E Williamson and Frank Emmert-Streib. Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data. BMC Systems Biology 2015 9:21 DOI 10.1186/s12918-015-0165-z

Mark W. Ruddock, Cherith N. Reid, Douglas McReynolds, John V. Lamont,  Stephen P. Fitzgerald & Kate E. Williamson (2014) Immunodetection of cytoplasmatic membrane-bound thrombomodulin in formalin-fixed paraffin-embedded human tissue microarrays. Molecular and Genetic Medicine (2014) Ruddock et al., J Mol Genet Med 2014, 8:4 http://dx.doi.org/10.4172/1747-0862.1000140

Frank Emmert-Streib, Funso Abogunrin, Ricardo de Matos Simoes, Brian Duggan, Mark W Ruddock,Cherith N Reid, Owen Roddy, Lisa White, Hugh F O’Kane, Declan O’Rourke, Neil H Anderson, Thiagarajan Nambirajan, Kate E Williamson. Collectives of diagnostic biomarkers identify high risk subpopulations of haematuria patients: exploiting heterogeneity in large-scale biomarker data. BMC Medicine 2013, 11:12 doi:10.1186/1741-7015-11-12

Cherith N. Reid, Michael Stevenson, Funso Abogunrin, Mark W. Ruddock, Frank Emmert-Streib, John V. Lamont, Kate E. Williamson (2012) Standardization of Diagnostic Biomarker Concentrations in Urine: The Hematuria Caveat Research Article PLOS ONE doi: 10.1371/journal.pone.0053354

Funso Abogunrin, Hugh F O’Kane, Mark W Ruddock, Michael Stevenson, Cherith N Reid, Joe M O’Sullivan, Neil H Anderson, Declan O’Rourke, Brian Duggan, John V Lamont, Ruth E Boyd, Peter Hamilton, Thiagarajan Nambirajan, Kate E Williamson. The impact of biomarkers in multivariate algorithms for bladder cancer diagnosis in patients with haematuria. Cancer (2012) 118(10):2641-50.

DOI: 10.1002/cncr.26544

Peer reviewed letter

Brian Duggan, Mark Ruddock, Kate Williamson Reply to the Impact of Biomarkers in Multivariate Algorithms for Bladder Cancer Diagnosis in Patients With Hematuria  DOI: 10.1002/cncr.27549, Published online: Month 00, 2012 in

Wiley Online Library (wileyonlinelibrary.com)

On line

UroToday - Beyond the Abstract Collectives of diagnostic biomarkers identify high-risk subpopulations of hematuria patients: exploiting heterogeneity in large-scale biomarker data http://www.urotoday.com/2014-09-18-02-47-34/bladder-cancer/57830-collectives- (submitted May 2013)

Williamson et al. Using algorithms to diagnose bladder cancer in Genitourinary Cancer

http://www.hcplive.com/media/pdf/08GenitourinaryCancer.pdf

UroToday - Beyond the Abstract - The impact of biomarkers in multivariate algorithms for bladder cancer diagnosis in patients with hematuria, by Kate E. Williamson PhD, et al. 3 March 2012

http://www.urotoday.com/bladder-cancer-1038/beyond-the-abstract-the-…osis-in-patients-with-hematuria-by-kate-e-williamson-phd-et-al.html

Awards

Award: Best Poster Paper

Authors: Ricardo de Matos Simoes, Sabine Dalleau, Frank Emmert-Streib and Kate E Williamson Title of poster paper: Muscle-invasive urothelial cancer gene regulatory network signatures inferred from large-scale gene expression data Name of Conference: The IEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2014 Place of conference: Belfast, UK Date of Award: 5/11/2014

Wolfson intercalated degree award ‘The relationship between matrix metalloproteinases and (MMPs) and tissue inhibitors of matrix metalloproteinases in urothelial cancer (Sarah Jackson, Intercalated BSc Student; Supervisors Kate Williamson and Sabine Dalleau) September 2014 – August 2015

Poster presentations / Talks

S. Dalleau, M. Stevenson, F. de Vocht, L.A. Anderson, D. Curry, B. Duggan, K. Young, K. Griffin, M. Ruddock, K. Williamson. Bladder cancer risk stratification of patients presenting with haematuria (HaBio study): individual cumulative exposure-based approach.  Accepted as a late breaking abstract for poster presentation at the International Society of Exposure Science (ISES) Nevada USA 18 – 22 October 2015

Ricardo de Matos Simoes, Brian Duggan, Mark W. Ruddock, Frank Emmert-Streib, Declan O'Rourke, Hugh F. O'Kane, Funso Abogunrin  Cherith N. Reid, Neil H Anderson, David Curry, Kate E. Williamson

Smoking and increased age in hematuric patients significantly confound the accuracy of classifiers for the diagnosis of urothelial cancer.

Poster presentation at the American Association of Cancer Research April 2014

Kate E Williamson, Frank Emmert-Streib, Michael Stevenson, Ricardo de Matos Simoes, Mark W Ruddock,Cherith N Reid, Hugh F O’Kane, Declan O’Rourke, Funso Abogunrin, Neil H Anderson, Brian Duggan. Collectives of protein biomarkers as risk stratifiers and diagnostic classifiers in haematuria.  

Invited talk URINOMICS 2013: First International Conference On Urine -OMICS) in Caparica Portugal 9th September 2013

Michael Stevenson, Cherith Reid, Brian Duggan, Mark Ruddock, Kate E Williamson.  Bladder cancer algorithms.

Poster presentation at the American Association of Cancer Research April 2013

Kate E Williamson, Mark Ruddock, Cherith Reid, Brian Duggan

The creation of diagnostic biochips for urothelial cancer in patients with haematuria

Poster presentation at BAUS Oncology Belfast 15-16 November 2012